Ticker · CUSIP 74168J101

PRME

PRIME MEDICINE INC

Healthcare·Biotechnology

···Share

Holders (tracked)

Combined shares

11,575,714

Combined value

$40.17M

Last close

$3.81

Quarter

2025Q4

Price is +9.8% vs the avg quarter-end implied price across tracked holders.

Price · 1Y$3.81+2.57 (+207.26%)H $6.67 · L $1.16 · Avg Vol 3.4M

Position opened

Tracked holders · last 8 quarters

+1 vs previous quarter over the last 8.

SEC event timeline

18 events

AQR Capital Management added2026-02-17
+1,610 shares · 2025Q4
Position
Ken Griffin (Citadel Advisors) trimmed2026-02-17
−787,272 shares · 2025Q4
Position
D.E. Shaw & Co. trimmed2026-02-17
−664,483 shares · 2025Q4
Position
Two Sigma Investments added2026-02-17
+1,181,657 shares · 2025Q4
Position
Steve Cohen (Point72) opened position2026-02-17
+551,030 shares · 2025Q4
Position
T. Rowe Price added2026-02-17
+30,051 shares · 2025Q4
Position
Wellington Management added2026-02-17
+42,902 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) trimmed2026-02-17
−1,367,128 shares · 2025Q4
Position
Renaissance Technologies added2026-02-12
+14,489 shares · 2025Q4
Position
Cathie Wood (ARK Invest) trimmed2026-02-11
−109,325 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) added2025-11-14
+1,270,467 shares · 2025Q3
Position
Two Sigma Investments added2025-11-14
+189,244 shares · 2025Q3
Position
Wellington Management opened position2025-11-14
+205,325 shares · 2025Q3
Position
AQR Capital Management trimmed2025-11-14
−10,144 shares · 2025Q3
Position
D.E. Shaw & Co. opened position2025-11-14
+2,215,852 shares · 2025Q3
Position
T. Rowe Price added2025-11-14
+9,182 shares · 2025Q3
Position
Renaissance Technologies added2025-11-13
+911,270 shares · 2025Q3
Position
Cathie Wood (ARK Invest) added2025-11-12
+3,155,182 shares · 2025Q3
Position

Insider activity

No insider transactions in the last 30 days.

View full insider history for PRME →

Follow-the-investor returns

If you'd copied each holder of PRME…

Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.

Investor	First in	Cost basis	Return	Position value today
AQR Capital Management	2024Q2	$2.32	+64.4%	$1.6M
Steve Cohen (Point72)	2024Q4	$3.40	+12.0%	$2.1M
Two Sigma Investments	2023Q3	$4.02	-5.3%	$6.2M
Ken Griffin (Citadel Advisors)	2023Q3	$4.16	-8.4%	$720K
Ken Griffin (Citadel Advisors)	2023Q3	$4.16	-8.4%	$720K
Ken Griffin (Citadel Advisors)	2023Q3	$4.16	-8.4%	$720K
Renaissance Technologies	2023Q4	$4.87	-21.8%	$4.4M
Wellington Management	2024Q2	$5.12	-25.6%	$946K
D.E. Shaw & Co.	2024Q2	$5.46	-30.2%	$5.9M
Izzy Englander (Millennium Mgmt)	2023Q1	$5.53	-31.1%	$196K
Cathie Wood (ARK Invest)	2022Q4	$7.94	-52.0%	$20.5M
T. Rowe Price	2022Q4	$10.63	-64.2%	$398K

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.

New positions1

Steve Cohen (Point72)
+551,030
$1.9M

Added to5

Two Sigma Investments
+1,181,657
$4.1M
Wellington Management
+42,902
$149K
Renaissance Technologies
+14,489
$50K
AQR Capital Management
+1,610
$6K
T. Rowe Price
+30,051
$104

Trimmed4

Izzy Englander (Millennium Mgmt)
−1,367,128
$4.7M
Ken Griffin (Citadel Advisors)
−787,272
$2.7M
D.E. Shaw & Co.
−664,483
$2.3M
Cathie Wood (ARK Invest)
−109,325
$379K

Exited0

—

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.

Quarter	Holders	Shares	Combined value	Δ holders
2022Q4	3	5,506,412	$102.3M	—
2023Q1	4	4,350,900	$53.5M	+1
2023Q2	4	7,928,806	$116.2M	—
2023Q3	7	8,241,042	$78.6M	+3
2023Q4	8	9,637,145	$85.4M	+1
2024Q1	10	13,811,042	$96.7M	+2
2024Q2	11	15,003,930	$77.1M	+1
2024Q3	9	9,988,539	$38.7M	-2
2024Q4	8	8,998,453	$26.3M	-1
2025Q1	9	7,541,142	$15.0M	+1
2025Q2	9	4,208,471	$10.4M	—
2025Q3	11	12,614,583	$69.9M	+2
2025Q4	12	11,575,714	$40.2M	+1

Who owns PRME

12 super-investors · 2025Q4

Tracked stake

11.58M

Combined value

$40M

% of shares outstanding

—

shares-out unknown

Quarter action mix

New1Added5Trim6

#	Manager	Shares	Value	% of book	Last action
1	Cathie Wood ARK Invest	5.37M	$19M	0.1%	Trim−109.3K
2	Two Sigma Investments	1.63M	$6M	0.0%	Added+1.18M
3	D.E. Shaw & Co.	1.55M	$5M	0.0%	Trim−664.5K
4	Renaissance Technologies	1.15M	$4M	0.0%	Added+14.5K
5	Steve Cohen Point72	551.0K	$2M	0.0%	New+551.0K
6	AQR Capital Management	415.8K	$1M	0.0%	Added+1.6K
7	Wellington Management	248.2K	$861K	0.0%	Added+42.9K
8	Ken Griffin Citadel Advisors	204.4K	$709K	0.0%	Trim−787.3K
9	Ken Griffin Citadel Advisors	189.1K	$656K	0.0%	Trim−787.3K
10	Ken Griffin Citadel Advisors	112.9K	$392K	0.0%	Trim−787.3K
11	T. Rowe Price	104.6K	$363K	0.0%	Added+30.1K
12	Izzy Englander Millennium Mgmt	51.3K	$178K	0.0%	Trim−1.37M

Recent moves

20 transactions

NEWSteve Cohen (Point72)
+551,030 · 2025Q4
ADDTwo Sigma Investments
+1,181,657 · 2025Q4
ADDAQR Capital Management
+1,610 · 2025Q4
ADDWellington Management
+42,902 · 2025Q4
TRIMD.E. Shaw & Co.
−664,483 · 2025Q4
ADDT. Rowe Price
+30,051 · 2025Q4
TRIMKen Griffin (Citadel Advisors)
−787,272 · 2025Q4
TRIMIzzy Englander (Millennium Mgmt)
−1,367,128 · 2025Q4
ADDRenaissance Technologies
+14,489 · 2025Q4
TRIMCathie Wood (ARK Invest)
−109,325 · 2025Q4
TRIMAQR Capital Management
−10,144 · 2025Q3
ADDIzzy Englander (Millennium Mgmt)
+1,270,467 · 2025Q3
ADDTwo Sigma Investments
+189,244 · 2025Q3
NEWD.E. Shaw & Co.
+2,215,852 · 2025Q3
ADDT. Rowe Price
+9,182 · 2025Q3
NEWWellington Management
+205,325 · 2025Q3
ADDRenaissance Technologies
+911,270 · 2025Q3
ADDCathie Wood (ARK Invest)
+3,155,182 · 2025Q3
TRIMIzzy Englander (Millennium Mgmt)
−1,631,949 · 2025Q2
TRIMT. Rowe Price
−1,501,872 · 2025Q2

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