Ticker · CUSIP 68401U204

OPRX

OPTIMIZERX CORP

Healthcare·Health Information Services

···Share

Holders (tracked)

Combined shares

299,750

Combined value

$3.67M

Last close

$7.17

Quarter

2025Q4

Price is -41.5% vs the avg quarter-end implied price across tracked holders.

Price · 1Y$7.17-1.28 (-15.15%)H $21.68 · L $5.93 · Avg Vol 348K

Position opened

Tracked holders · last 8 quarters

+1 vs previous quarter over the last 8.

SEC event timeline

12 events

Ken Griffin (Citadel Advisors) trimmed2026-02-17
−96,815 shares · 2025Q4
Position
D.E. Shaw & Co. trimmed2026-02-17
−208,184 shares · 2025Q4
Position
Two Sigma Investments trimmed2026-02-17
−17,523 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) opened position2026-02-17
+43,669 shares · 2025Q4
Position
Steve Cohen (Point72) opened position2026-02-17
+11,965 shares · 2025Q4
Position
AQR Capital Management added2026-02-17
+2,256 shares · 2025Q4
Position
Renaissance Technologies trimmed2026-02-12
−78,322 shares · 2025Q4
Position
AQR Capital Management opened position2025-11-14
+12,258 shares · 2025Q3
Position
Izzy Englander (Millennium Mgmt) exited2025-11-14
−17,593 shares · 2025Q3
Position
Two Sigma Investments trimmed2025-11-14
−39,041 shares · 2025Q3
Position
D.E. Shaw & Co. trimmed2025-11-14
−91,845 shares · 2025Q3
Position
Renaissance Technologies added2025-11-13
+30,193 shares · 2025Q3
Position

Insider activity

No insider transactions in the last 30 days.

View full insider history for OPRX →

Follow-the-investor returns

If you'd copied each holder of OPRX…

Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.

Investor	First in	Cost basis	Return	Position value today
Izzy Englander (Millennium Mgmt)	2018Q3	$11.18	-35.9%	$313K
D.E. Shaw & Co.	2020Q4	$12.83	-44.1%	$809K
Two Sigma Investments	2019Q2	$15.42	-53.5%	$331K
Renaissance Technologies	2019Q2	$15.48	-53.7%	$212K
Ken Griffin (Citadel Advisors)	2020Q4	$18.75	-61.8%	$86K
Ken Griffin (Citadel Advisors)	2020Q4	$18.75	-61.8%	$86K
Steve Cohen (Point72)	2021Q4	$29.10	-75.4%	$86K
AQR Capital Management	2019Q3	$34.01	-78.9%	$104K

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.

New positions2

Izzy Englander (Millennium Mgmt)
+43,669
$535K
Steve Cohen (Point72)
+11,965
$147K

Added to1

AQR Capital Management
+2,256
$28K

Trimmed4

D.E. Shaw & Co.
−208,184
$2.6M
Ken Griffin (Citadel Advisors)
−96,815
$1.2M
Renaissance Technologies
−78,322
$960K
Two Sigma Investments
−17,523
$215K

Exited0

—

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.

Quarter	Holders	Shares	Combined value	Δ holders
2022Q1	8	3,098,874	$116.9M	—
2022Q2	8	2,928,917	$80.2M	—
2022Q3	11	3,799,404	$56.3M	+3
2022Q4	10	3,435,633	$57.7M	-1
2023Q1	11	3,079,136	$45.0M	+1
2023Q2	11	2,741,247	$39.2M	—
2023Q3	8	1,964,878	$15.3M	-3
2023Q4	9	1,562,818	$22.4M	+1
2024Q1	7	1,324,711	$16.1M	-2
2024Q2	8	1,829,275	$18.3M	+1
2024Q3	6	471,470	$3.6M	-2
2024Q4	4	372,166	$1.8M	-2
2025Q1	6	684,836	$5.9M	+2
2025Q2	7	936,887	$12.6M	+1
2025Q3	7	695,404	$14.3M	—
2025Q4	8	299,750	$3.7M	+1

Who owns OPRX

8 super-investors · 2025Q4

Tracked stake

299.8K

Combined value

$4M

% of shares outstanding

—

shares-out unknown

Quarter action mix

New2Added1Trim5

#	Manager	Shares	Value	% of book	Last action
1	D.E. Shaw & Co.	112.9K	$1M	0.0%	Trim−208.2K
2	Two Sigma Investments	46.2K	$566K	0.0%	Trim−17.5K
3	Izzy Englander Millennium Mgmt	43.7K	$535K	0.0%	New+43.7K
4	Renaissance Technologies	29.6K	$363K	0.0%	Trim−78.3K
5	Ken Griffin Citadel Advisors	29.0K	$356K	0.0%	Trim−96.8K
6	AQR Capital Management	14.5K	$178K	0.0%	Added+2.3K
7	Ken Griffin Citadel Advisors	12.0K	$147K	0.0%	Trim−96.8K
8	Steve Cohen Point72	12.0K	$147K	0.0%	New+12.0K

Recent moves

20 transactions

ADDAQR Capital Management
+2,256 · 2025Q4
NEWIzzy Englander (Millennium Mgmt)
+43,669 · 2025Q4
TRIMKen Griffin (Citadel Advisors)
−96,815 · 2025Q4
NEWSteve Cohen (Point72)
+11,965 · 2025Q4
TRIMD.E. Shaw & Co.
−208,184 · 2025Q4
TRIMTwo Sigma Investments
−17,523 · 2025Q4
TRIMRenaissance Technologies
−78,322 · 2025Q4
TRIMTwo Sigma Investments
−39,041 · 2025Q3
SOLDIzzy Englander (Millennium Mgmt)
−17,593 · 2025Q3
TRIMD.E. Shaw & Co.
−91,845 · 2025Q3
NEWAQR Capital Management
+12,258 · 2025Q3
ADDRenaissance Technologies
+30,193 · 2025Q3
TRIMIzzy Englander (Millennium Mgmt)
−73,013 · 2025Q2
ADDTwo Sigma Investments
+53,709 · 2025Q2
ADDD.E. Shaw & Co.
+62,977 · 2025Q2
NEWRenaissance Technologies
+77,707 · 2025Q2
NEWIzzy Englander (Millennium Mgmt)
+90,606 · 2025Q1
NEWTwo Sigma Investments
+49,036 · 2025Q1
ADDD.E. Shaw & Co.
+54,202 · 2025Q1
SOLDIzzy Englander (Millennium Mgmt)
−45,637 · 2024Q4

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