Ticker · CUSIP 501147102

KRYS

KRYSTAL BIOTECH INC

Healthcare·Biotechnology

···Share

Holders (tracked)

Combined shares

1,283,883

Combined value

$316.53M

Last close

$274.21

Quarter

2025Q4

Price is +11.2% vs the avg quarter-end implied price across tracked holders.

Price · 1Y$274.21+105.64 (+62.67%)H $291.93 · L $123.36 · Avg Vol 327K

Tracked holders · last 8 quarters

+4 vs previous quarter over the last 8.

SEC event timeline

20 events

Paul Tudor Jones (Tudor Investment) opened position2026-02-17
+1,375 shares · 2025Q4
Position
Ken Griffin (Citadel Advisors) trimmed2026-02-17
−250,483 shares · 2025Q4
Position
D.E. Shaw & Co. trimmed2026-02-17
−4,706 shares · 2025Q4
Position
AQR Capital Management trimmed2026-02-17
−5,976 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) trimmed2026-02-17
−134,055 shares · 2025Q4
Position
T. Rowe Price added2026-02-17
+62,897 shares · 2025Q4
Position
Wellington Management trimmed2026-02-17
−230 shares · 2025Q4
Position
Ray Dalio (Bridgewater Associates) added2026-02-13
+292 shares · 2025Q4
Position
Renaissance Technologies opened position2026-02-12
+3,300 shares · 2025Q4
Position
Norges Bank (Norway SWF) opened position2026-02-10
+284,573 shares · 2025Q4
Position
Ken Fisher (Fisher Asset Mgmt) opened position2026-02-09
+3,786 shares · 2025Q4
Position
AQR Capital Management added2025-11-14
+8,165 shares · 2025Q3
Position
Izzy Englander (Millennium Mgmt) added2025-11-14
+136,151 shares · 2025Q3
Position
D.E. Shaw & Co. trimmed2025-11-14
−4,913 shares · 2025Q3
Position
T. Rowe Price added2025-11-14
+205,675 shares · 2025Q3
Position
Wellington Management added2025-11-14
+728 shares · 2025Q3
Position
Ray Dalio (Bridgewater Associates) opened position2025-11-13
+9,723 shares · 2025Q3
Position
Renaissance Technologies exited2025-11-13
−89,800 shares · 2025Q3
Position
Norges Bank (Norway SWF) exited2025-11-13
−282,706 shares · 2025Q3
Position
Norges Bank (Norway SWF) added2025-11-12
+232,757 shares · 2024Q3
Position

Insider activity

No insider transactions in the last 30 days.

View full insider history for KRYS →

Follow-the-investor returns

If you'd copied each holder of KRYS…

Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.

Investor	First in	Cost basis	Return	Position value today
Paul Tudor Jones (Tudor Investment)	2021Q4	$69.97	+291.9%	$377K
Renaissance Technologies	2018Q3	$126.32	+117.1%	$905K
AQR Capital Management	2019Q2	$151.54	+80.9%	$3.9M
T. Rowe Price	2018Q4	$167.83	+63.4%	$145.3M
Norges Bank (Norway SWF)	2020Q1	$168.55	+62.7%	$78.0M
D.E. Shaw & Co.	2021Q2	$169.96	+61.3%	$578K
Izzy Englander (Millennium Mgmt)	2017Q4	$176.85	+55.0%	$4.0M
Ray Dalio (Bridgewater Associates)	2025Q3	$178.57	+53.6%	$2.7M
Wellington Management	2024Q1	$179.06	+53.1%	$2.9M
Ken Griffin (Citadel Advisors)	2019Q1	$243.12	+12.8%	$1.1M
Ken Griffin (Citadel Advisors)	2019Q1	$243.12	+12.8%	$1.1M
Ken Griffin (Citadel Advisors)	2019Q1	$243.12	+12.8%	$1.1M
Ken Fisher (Fisher Asset Mgmt)	2023Q1	$245.26	+11.8%	$1.0M

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.

New positions4

Norges Bank (Norway SWF)
+284,573
$70.2M
Ken Fisher (Fisher Asset Mgmt)
+3,786
$933K
Renaissance Technologies
+3,300
$814K
Paul Tudor Jones (Tudor Investment)
+1,375
$339K

Added to2

Ray Dalio (Bridgewater Associates)
+292
$72K
T. Rowe Price
+62,897
$16K

Trimmed5

Ken Griffin (Citadel Advisors)
−250,483
$61.8M
Izzy Englander (Millennium Mgmt)
−134,055
$33.0M
AQR Capital Management
−5,976
$1.5M
D.E. Shaw & Co.
−4,706
$1.2M
Wellington Management
−230
$57K

Exited0

—

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.

Quarter	Holders	Shares	Combined value	Δ holders
2022Q1	8	3,464,992	$230.6M	—
2022Q2	8	3,393,749	$222.8M	—
2022Q3	10	2,911,514	$202.9M	+2
2022Q4	11	2,417,860	$191.5M	+1
2023Q1	10	2,423,199	$194.0M	-1
2023Q2	10	2,633,652	$309.2M	—
2023Q3	10	2,780,705	$322.6M	—
2023Q4	9	2,340,871	$290.4M	-1
2024Q1	11	2,676,630	$476.3M	+2
2024Q2	11	4,639,553	$852.0M	—
2024Q3	12	910,751	$165.8M	+1
2024Q4	11	843,624	$132.2M	-1
2025Q1	10	570,667	$102.9M	-1
2025Q2	10	754,859	$103.8M	—
2025Q3	9	1,344,510	$237.3M	-1
2025Q4	13	1,283,883	$316.5M	+4

Who owns KRYS

13 super-investors · 2025Q4

Tracked stake

1.28M

Combined value

$317M

% of shares outstanding

—

shares-out unknown

Quarter action mix

New4Added2Trim7

#	Manager	Shares	Value	% of book	Last action
1	T. Rowe Price	530.0K	$131M	0.0%	Added+62.9K
2	Ken Griffin Citadel Advisors	386.5K	$95M	0.0%	Trim−250.5K
3	Norges Bank Norway SWF	284.6K	$70M	0.0%	New+284.6K
4	Ken Griffin Citadel Advisors	18.7K	$5M	0.0%	Trim−250.5K
5	Izzy Englander Millennium Mgmt	14.7K	$4M	0.0%	Trim−134.1K
6	AQR Capital Management	14.2K	$3M	0.0%	Trim−6.0K
7	Wellington Management	10.7K	$3M	0.0%	Trim−230
8	Ray Dalio Bridgewater Associates	10.0K	$2M	0.0%	Added+292
9	Ken Griffin Citadel Advisors	4.1K	$1M	0.0%	Trim−250.5K
10	Ken Fisher Fisher Asset Mgmt	3.8K	$933K	0.0%	New+3.8K
11	Renaissance Technologies	3.3K	$814K	0.0%	New+3.3K
12	D.E. Shaw & Co.	2.1K	$520K	0.0%	Trim−4.7K
13	Paul Tudor Jones Tudor Investment	1.4K	$339K	0.0%	New+1.4K

Recent moves

20 transactions

TRIMWellington Management
−230 · 2025Q4
ADDT. Rowe Price
+62,897 · 2025Q4
TRIMIzzy Englander (Millennium Mgmt)
−134,055 · 2025Q4
TRIMAQR Capital Management
−5,976 · 2025Q4
TRIMD.E. Shaw & Co.
−4,706 · 2025Q4
NEWPaul Tudor Jones (Tudor Investment)
+1,375 · 2025Q4
TRIMKen Griffin (Citadel Advisors)
−250,483 · 2025Q4
ADDRay Dalio (Bridgewater Associates)
+292 · 2025Q4
NEWRenaissance Technologies
+3,300 · 2025Q4
NEWNorges Bank (Norway SWF)
+284,573 · 2025Q4
NEWKen Fisher (Fisher Asset Mgmt)
+3,786 · 2025Q4
ADDAQR Capital Management
+8,165 · 2025Q3
ADDIzzy Englander (Millennium Mgmt)
+136,151 · 2025Q3
TRIMD.E. Shaw & Co.
−4,913 · 2025Q3
ADDT. Rowe Price
+205,675 · 2025Q3
ADDWellington Management
+728 · 2025Q3
SOLDRenaissance Technologies
−89,800 · 2025Q3
NEWRay Dalio (Bridgewater Associates)
+9,723 · 2025Q3
SOLDNorges Bank (Norway SWF)
−282,706 · 2025Q3
ADDNorges Bank (Norway SWF)
+232,757 · 2024Q3

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