Ticker · CUSIP 48576U205

KPTI

KARYOPHARM THERAPEUTICS INC
···Share
Holders (tracked)
7
Combined shares
368,024
Combined value
$2.71M
Last close
$8.61
Quarter
2025Q4
Price · 1Y$8.61+3.66 (+73.94%)H $10.09 · L $3.77 · Avg Vol 385K
Position opened
$4.00$6.00$8.00$10.00VolJul 25Oct 25Jan 26Apr 26
Tracked holders · last 8 quarters
+3 vs previous quarter over the last 4.
752025Q12025Q4
Price is +16.9% vs the avg quarter-end implied price across tracked holders.

SEC event timeline

6 events
  1. +31,709 shares · 2025Q4
    Position
  2. +148,793 shares · 2025Q4
    Position
  3. +12,922 shares · 2025Q4
    Position
  4. −4,800 shares · 2025Q4
    Position
  5. −31,847 shares · 2025Q3
    Position
  6. −1,100 shares · 2025Q3
    Position

Insider activity

No insider transactions in the last 30 days.
Follow-the-investor returns
If you'd copied each holder of KPTI…
Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.
InvestorFirst inCost basisReturnPosition value today
Renaissance Technologies2025Q1$3.78+127.8%$516K
T. Rowe Price2025Q2$4.32+99.4%$94K
Ken Griffin (Citadel Advisors)2025Q1$6.65+29.5%$614K
Ken Griffin (Citadel Advisors)2025Q1$6.65+29.5%$614K
Ken Griffin (Citadel Advisors)2025Q1$6.65+29.5%$614K
Two Sigma Investments2025Q4$7.36+17.0%$1.3M
Paul Tudor Jones (Tudor Investment)2025Q4$7.36+17.0%$111K

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.
Added to0
Trimmed1
Exited0

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.
QuarterHoldersCombined value
2025Q1
5
$1.3M
2025Q2
5
$1.4M
2025Q3
4
$1.1M
2025Q4
7
$2.7M

Who owns KPTI

7 super-investors · 2025Q4
Tracked stake
368.0K
shares
Combined value
$3M
% of shares outstanding
shares-out unknown
Quarter action mix
New5Trim1Held1
#ManagerSharesValue
1Two Sigma Investments148.8K$1M
2Ken Griffin
Citadel Advisors
71.3K$525K
3Renaissance Technologies59.9K$441K
4Ken Griffin
Citadel Advisors
32.5K$239K
5Ken Griffin
Citadel Advisors
31.7K$233K
6Paul Tudor Jones
Tudor Investment
12.9K$95K
7T. Rowe Price10.9K$81K

Recent moves

11 transactions
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