Ticker · CUSIP 03237H101

AMLX

AMYLYX PHARMACEUTICALS INC

Healthcare·Drug Manufacturers - Specialty & Generic

···Share

Holders (tracked)

Combined shares

1,832,027

Combined value

$22.13M

Last close

$18.36

Quarter

2025Q4

Price is +52.0% vs the avg quarter-end implied price across tracked holders.

Price · 1Y$18.36+14.38 (+361.31%)H $18.36 · L $3.98 · Avg Vol 1.5M

Position opened

Tracked holders · last 8 quarters

Flat over the last 8 quarters.

SEC event timeline

19 events

D.E. Shaw & Co. added2026-02-17
+4,347 shares · 2025Q4
Position
Ken Griffin (Citadel Advisors) added2026-02-17
+110,295 shares · 2025Q4
Position
Two Sigma Investments added2026-02-17
+245,985 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) trimmed2026-02-17
−371,316 shares · 2025Q4
Position
Steve Cohen (Point72) trimmed2026-02-17
−2,455,066 shares · 2025Q4
Position
T. Rowe Price added2026-02-17
+7,103 shares · 2025Q4
Position
Paul Tudor Jones (Tudor Investment) opened position2026-02-17
+22,402 shares · 2025Q4
Position
Wellington Management trimmed2026-02-17
−10,415 shares · 2025Q4
Position
AQR Capital Management trimmed2026-02-17
−45,793 shares · 2025Q4
Position
Renaissance Technologies added2026-02-12
+172,600 shares · 2025Q4
Position
Paul Tudor Jones (Tudor Investment) exited2025-12-09
−12,073 shares · 2025Q3
Position
Steve Cohen (Point72) trimmed2025-11-14
−1,746,200 shares · 2025Q3
Position
Two Sigma Investments trimmed2025-11-14
−460,430 shares · 2025Q3
Position
Izzy Englander (Millennium Mgmt) trimmed2025-11-14
−1,094,287 shares · 2025Q3
Position
D.E. Shaw & Co. trimmed2025-11-14
−82,625 shares · 2025Q3
Position
T. Rowe Price added2025-11-14
+9,053 shares · 2025Q3
Position
Wellington Management trimmed2025-11-14
−52,421 shares · 2025Q3
Position
AQR Capital Management opened position2025-11-14
+73,640 shares · 2025Q3
Position
Renaissance Technologies trimmed2025-11-13
−376,300 shares · 2025Q3
Position

Insider activity

No insider transactions in the last 30 days.

View full insider history for AMLX →

Follow-the-investor returns

If you'd copied each holder of AMLX…

Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.

Investor	First in	Cost basis	Return	Position value today
AQR Capital Management	2023Q1	$2.07	+785.8%	$511K
Izzy Englander (Millennium Mgmt)	2022Q1	$3.32	+453.7%	$853K
Wellington Management	2022Q4	$5.36	+242.3%	$4.1M
Steve Cohen (Point72)	2022Q2	$5.83	+214.9%	$6.2M
Two Sigma Investments	2023Q4	$9.62	+90.9%	$6.3M
Renaissance Technologies	2022Q1	$11.23	+63.5%	$3.5M
T. Rowe Price	2022Q4	$11.40	+61.1%	$2.0M
Ken Griffin (Citadel Advisors)	2022Q1	$12.03	+52.6%	$2.1M
Ken Griffin (Citadel Advisors)	2022Q1	$12.03	+52.6%	$2.1M
Paul Tudor Jones (Tudor Investment)	2022Q3	$12.15	+51.1%	$411K
D.E. Shaw & Co.	2022Q3	$19.97	-8.0%	$1.3M

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.

New positions1

Paul Tudor Jones (Tudor Investment)
+22,402
$271K

Added to5

Two Sigma Investments
+245,985
$3.0M
Renaissance Technologies
+172,600
$2.1M
Ken Griffin (Citadel Advisors)
+110,295
$1.3M
D.E. Shaw & Co.
+4,347
$53K
T. Rowe Price
+7,103
$86

Trimmed4

Steve Cohen (Point72)
−2,455,066
$29.7M
Izzy Englander (Millennium Mgmt)
−371,316
$4.5M
AQR Capital Management
−45,793
$553K
Wellington Management
−10,415
$126K

Exited0

—

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.

Quarter	Holders	Shares	Combined value	Δ holders
2022Q1	5	8,528,154	$109.6M	—
2022Q2	8	9,753,383	$187.9M	+3
2022Q3	10	11,260,192	$317.0M	+2
2022Q4	14	13,225,181	$488.7M	+4
2023Q1	14	10,723,006	$314.6M	—
2023Q2	13	11,218,997	$242.0M	-1
2023Q3	13	11,172,547	$204.6M	—
2023Q4	15	16,175,086	$238.1M	+2
2024Q1	13	12,689,756	$36.0M	-2
2024Q2	10	12,572,487	$23.9M	-3
2024Q3	10	4,641,358	$15.0M	—
2024Q4	10	4,526,974	$17.1M	—
2025Q1	11	8,748,664	$31.0M	+1
2025Q2	10	8,834,482	$56.6M	-1
2025Q3	11	4,177,085	$56.8M	+1
2025Q4	11	1,832,027	$22.1M	—

Who owns AMLX

11 super-investors · 2025Q4

Tracked stake

1.83M

Combined value

$22M

% of shares outstanding

—

shares-out unknown

Quarter action mix

New1Added6Trim4

#	Manager	Shares	Value	% of book	Last action
1	Ken Griffin Citadel Advisors	345.0K	$4M	0.0%	Added+110.3K
2	Two Sigma Investments	344.4K	$4M	0.0%	Added+246.0K
3	Steve Cohen Point72	335.0K	$4M	0.0%	Trim−2.46M
4	Wellington Management	225.8K	$3M	0.0%	Trim−10.4K
5	Renaissance Technologies	192.5K	$2M	0.0%	Added+172.6K
6	Ken Griffin Citadel Advisors	111.9K	$1M	0.0%	Added+110.3K
7	T. Rowe Price	107.5K	$1M	0.0%	Added+7.1K
8	D.E. Shaw & Co.	73.2K	$885K	0.0%	Added+4.3K
9	Izzy Englander Millennium Mgmt	46.5K	$561K	0.0%	Trim−371.3K
10	AQR Capital Management	27.8K	$336K	0.0%	Trim−45.8K
11	Paul Tudor Jones Tudor Investment	22.4K	$271K	0.0%	New+22.4K

Recent moves

20 transactions

TRIMWellington Management
−10,415 · 2025Q4
TRIMAQR Capital Management
−45,793 · 2025Q4
TRIMSteve Cohen (Point72)
−2,455,066 · 2025Q4
NEWPaul Tudor Jones (Tudor Investment)
+22,402 · 2025Q4
ADDKen Griffin (Citadel Advisors)
+110,295 · 2025Q4
TRIMIzzy Englander (Millennium Mgmt)
−371,316 · 2025Q4
ADDTwo Sigma Investments
+245,985 · 2025Q4
ADDT. Rowe Price
+7,103 · 2025Q4
ADDD.E. Shaw & Co.
+4,347 · 2025Q4
ADDRenaissance Technologies
+172,600 · 2025Q4
SOLDPaul Tudor Jones (Tudor Investment)
−12,073 · 2025Q3
NEWAQR Capital Management
+73,640 · 2025Q3
TRIMSteve Cohen (Point72)
−1,746,200 · 2025Q3
TRIMD.E. Shaw & Co.
−82,625 · 2025Q3
TRIMIzzy Englander (Millennium Mgmt)
−1,094,287 · 2025Q3
ADDT. Rowe Price
+9,053 · 2025Q3
TRIMWellington Management
−52,421 · 2025Q3
TRIMTwo Sigma Investments
−460,430 · 2025Q3
TRIMRenaissance Technologies
−376,300 · 2025Q3
TRIMIzzy Englander (Millennium Mgmt)
−1,569,795 · 2025Q2

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